动脉粥样硬化研究模型的多维审视与创新探索

Multidimensional review and innovative exploration of atherosclerosis research models

摘要:

动脉粥样硬化(As)是严重威胁人类健康的慢性病变,也是心血管疾病发生的重要病理基础,其发病机制的研究高度依赖实验模型。然而,现有模型普遍存在建模周期长、成功率低、人体病变模拟度不足等问题,制约了机制解析与转化研究的深入开展。本综述旨在系统阐述当前主流As模型的建模方法,全面比较现有模型的技术革新点,构建多维度标准化评价体系与跨学科整合方向,以期为探索更优化的As研究模型提供参考。

Abstract:

Atherosclerosis (As) is a chronic disease that seriously threatens human health and is an important pathological basis for cardiovascular diseases. The research on its pathogenesis highly depends on experimental models. However, the existing models may have shortcomings such as long modeling period, low success rate, and insufficient simulation of human pathological lesions, which restrict the mechanism analysis and translational research. This review aims to elaborate on the current mainstream As model construction methods, systematically compare the technological innovation points of existing models, and construct a multi-dimensional standardized evaluation system and interdisciplinary integration strategies, in order to explore more optimized As research models.