巨噬细胞在主动脉夹层中的作用机制与干预靶点

The role of macrophages in aortic dissection:mechanisms and therapeutic targets

摘要:

主动脉夹层(AD)是一种高致死率的心血管急危重症,其发生发展与血管壁炎症、细胞外基质(ECM)降解及血管重塑密切相关。巨噬细胞作为关键的免疫调节细胞,在AD进程中扮演着核心角色。本文系统综述了巨噬细胞参与AD发生发展的最新研究进展,重点阐述其通过复杂的炎症与代谢调控机制以及细胞间交互网络,深度参与AD进程的多种途径。深入理解巨噬细胞的异质性亚群及其作用机制,将为开发靶向巨噬细胞的新型精准诊疗策略提供重要的理论依据,展现出显著的临床转化潜力。

Abstract:

Aortic Dissection (AD) is a critical cardiovascular disease with a high mortality rate. Its initiation and progression are closely associated with vascular wall inflammation, extracellular matrix (ECM) degradation, and vascular remodeling. Macrophages, as key immunoregulatory cells, play a central role in the process of AD. This article systematically reviews the latest research advances on the involvement of macrophages in the development and progression of AD, with a focus on elucidating the multiple pathways through which macrophages deeply participate in AD via complex inflammatory and metabolic regulatory mechanisms as well as intercellular interaction networks. An in-depth understanding of the heterogeneous subsets of macrophages and their mechanisms of action will provide an important theoretical basis for the development of novel precision diagnostic and therapeutic strategies targeting macrophages, demonstrating significant clinical translational potential.