长链非编码RNA在血管重构中的作用及机制进展

Progress in the role and mechanisms of long non-coding RNA in vascular remodeling

摘要:

血管重构是心血管疾病的核心病理过程,近年来其表观遗传作用机制得到了广泛关注。长链非编码RNA(lncRNA)作为重要的调控分子,通过复杂的调控网络参与血管重构的调控。文章系统探讨了lncRNA在血管重构中的作用,重点分析了其通过表观遗传修饰、染色质的三维结构重构及竞争性内源RNA(ceRNA)等机制,在影响内皮细胞功能、血管平滑肌细胞表型转换及细胞外基质代谢紊乱等关键环节所发挥的调控作用。

Abstract:

Vascular remodeling constitutes a central pathological process in cardiovascular diseases, with its epigenetic mechanisms attracting considerable attention in recent years. Long non-coding RNA (lncRNA), as pivotal regulatory molecules, participate in the modulation of vascular remodeling through intricate regulatory networks. This paper systematically explores the functions of lncRNA in vascular remodeling, and further elaborates their regulatory roles in key biological processes including endothelial cell function, phenotypic switching of vascular smooth muscle cell (VSMC), and extracellular matrix metabolic dysregulation through multiple mechanisms such as epigenetic modifications, three-dimensional chromatin remodeling, and competing endogenous RNA (ceRNA) regulatory networks.