血清铁蛋白与颈动脉粥样硬化和脑梗死的关系

Relationship Between Serum Ferritin and Carotid Atherosclerosis,Cerebral Infarction

摘要:

目的探讨血清铁蛋白与脑梗死和颈动脉粥样硬化的关系。方法对133例脑梗死患者和92例对照者行颈动脉血管彩超检测,观察颈动脉内膜—中膜厚度、颈动脉有无斑块及斑块评分和管腔的狭窄率,作为评价颈动脉粥样硬化的指标。用酶联免疫吸附法检测血清铁蛋白的水平。比较脑梗死组和对照组血清铁蛋白水平的差异,及颈动脉内膜—中膜厚度、斑块评分与血清铁蛋白的关系。结果脑梗死组颈动脉粥样硬化的患病率(70.6%)较对照组(39.5%)明显增高,脑梗死组血清铁蛋白水平较对照组明显升高(248.5±107.4μg/L比197.6±94.8μg/L,p<0.05);对颈动脉粥样硬化的各主要危险因素行有序分类Logistic回归分析显示,血清铁蛋白、血压控制情况和年龄进入回归方程。血清铁蛋白水平与颈动脉内膜—中膜厚度及斑块评分之间呈正相关,偏相关系数分别为0.56和0.48(p<0.05);血清铁蛋白与低密度脂蛋白胆固醇水平呈正相关,Pearson积距相关系数为0.51(p<0.05)。结论脑梗死组血清铁蛋白水平较对照组高,血清铁蛋白与颈动脉粥样硬化的严重程度呈正相关。

Abstract:

Aim To observe the serum ferritin (SF) expression in cerebral infarction and carotid atherosclerosis. Methods Carotid atherosclerosis of all enrolled patients were evaluated by ultrasonography and the level of SF were detected in blood plasma. The SF content in cerebral infarction group was compared with control group; the relationship between SF and carotid interia-media thickness (IMT)/carotid plaque scores was analysed. Results 77 (70.6%)patients were detected to have carotid atherosclerosis in cerebral infarction group, and 30 (39.5%) patients were detected to have carotid atherosclerosis in control group. The level of SF in cerebral infarction group was higher than that in control group (248.5±107.4 μg/L vs 197.6±94.8 μg/L, p<0.05). Partial correlation analysis of SF and carotid IMT/ plaque scores showed positive correlation, and the partial coefficient were 0.56 and 0.48 respectively (p<0.05). The level of SF was positively correlated with low density lipoprotein in plasma, and the pearson coefficient was 0.51 (p<0.05). Conclusions The SF level increases in cerebral infarction patients; the level of SF is positively correlated with the severity of carotid atherosclerosis.