巨噬细胞移出动脉粥样硬化斑块调控机制

Egression of Macrophages from Regressive Plaques in Atherosclerosis

摘要:

巨噬细胞对动脉粥样硬化斑块的发生发展及不稳定起着关键作用，减少斑块中巨噬细胞累积对逆转斑块起着尤为重要的作用。诱导巨噬细胞移出斑块是减少斑块中巨噬细胞数量的主要策略之一。文章以诱导巨噬细胞移出斑块的受体CCR7及抑制巨噬细胞移出斑块的受体UNC5b、PlexinD1及氧化应激为主线，介绍相关调控机制研究进展。

关键词:动脉粥样硬化;巨噬细胞;CCR7;UNC5b;PlexinD1动脉粥样硬化;巨噬细胞;CCR7;UNC5b;PlexinD1

Abstract:

Macrophages plays an important role in atherosclerotic plaque development, progression and destabilization, then reduction of macrophages in plaque promotes the regression of atherosclerotic plaques. Emigration of macrophages from plaques is one approach for reduction of macrophages in plaques, so this paper reviewed activated receptor CCR7, inhibited receptors UNC5b and PlexinD1, oxidative stress in egression of macrophage from plaque.

Key words:Atherosclerosis Macrophage CCR7 UNC5b PlexinD1