血浆小而密低密度脂蛋白胆固醇水平与颈总动脉内膜中膜厚度的相关性

Correlation Between Plasma Levels of Small, Dense Low Density Lipoprotein Cholesterol and Common Carotid Artery Intima-media Thickness

摘要:

目的 评估测定颈总动脉内膜中膜厚度增厚患者小而密低密度脂蛋白胆固醇含量的价值。方法 吴江区第一人民医院2012年6月～2013年6月期间在体检中心行颈动脉超声的体检者130例，经颈动脉彩色多普勒超声检查，以颈总动脉内膜中膜厚度≥0.9 mm作为异常标准，分为正常组62例和增厚组68例；检测这些体检者的血浆小而密低密度脂蛋白胆固醇水平，并与颈总动脉内膜中膜厚度进行相关性分析。结果 颈总动脉内膜中膜厚度增厚组小而密低密度脂蛋白胆固醇显著高于正常组（43.97±11.35 mg/dL比26.01±7.62 mg/dL,P＜0.001），且增厚组小而密低密度脂蛋白胆固醇与颈总动脉内膜中膜厚度厚度显著正相关 （r0.857,P＜0.001）。结论 小而密低密度脂蛋白胆固醇水平对颈总动脉内膜中膜厚度的评价具有价值。

Abstract:

Aim To determine whether small, dense low density lipoprotein cholesterol （sdLDLC） affects common carotid artery intima-media thickness （CCA-IMT） or not. Methods 130 patients who had dyslipidemia, diabetes mellitus, hypertension, or smokers participated in this experiment. SdLDLC was collected from automatic analyzer, and CCA-IMT analysis datas were obtained from high-resolution B-mode ultrasound. Results The sdLDLC in CCA-IMT thickening group was significantly higher than that in CCA-IMT normal group （43.97 ± 11.35 mg/dL vs 26.01 ± 7.62 mg/dL, P＜0.001）. The positive association of CCA-IMT with sdLDLC was significant （r0.857, P＜0001）. Conclusions This result indicates that sdLDLC was the best marker of CCA-IMT and suggests that quantitative measurement of sdLDLC provides useful information for the risk assessment of CCA-IMT.