急性心肌梗死患者血清半乳糖凝集素3水平与冠状动脉病变的相关性

Correlation Between Galectin-3 and Coronary Lesion in Patients with Acute Myocardial Infarction

摘要:

目的 探讨半乳糖凝集素3（Gal-3）与急性心肌梗死（AMI）患者冠状动脉病变程度的相关性。方法 收集行急诊冠状动脉造影且确诊为AMI的患者共31例，并收集30例冠状动脉造影正常的非冠心病患者作为对照组。采集入选病例一般临床资料，检测其血清Gal-3、单核细胞趋化蛋白1及血浆高敏C反应蛋白浓度，通过Gensini评分系统对冠状动脉病变程度进行评分，通过分析Gal-3水平及其与单核细胞趋化蛋白1、高敏C反应蛋白和冠状动脉Gensini积分间的相关性，探讨Gal-3与AMI患者冠状动脉病变程度的关系。结果 AMI患者血清Gal-3水平明显高于对照组（P<0.05）；Gal-3水平与高敏C反应蛋白、单核细胞趋化蛋白1水平呈显著正相关（P<0.05）；Gal-3与AMI患者冠状动脉Gensin积分呈显著正相关（P<0.05）。结论 血清Gal-3水平在某种程度上可反映AMI患者冠状动脉病变程度。

Abstract:

Aim This study was designed to investigate the correlation between serum galectin-3 （Gal-3） levels and coronary lesion in patients with acute myocardial infarction. Methods This study included 31 patients with acute myocardial infarction that were confirmed by coronary angiography. Thirty non-coronary heart disease subjects confirmed by coronary angiography were recruited as control group. General clinical data of all the subjects were collected, the concentration of serum Gal-3, monocyte chemotactic protein-1 （MCP-1） and plasma high-sensitive C-reactive protein （hs-CRP） were assayed. And the degree of coronary arterial lesion were calculated by Gensini cumulative index. Results The levels of serum Gal-3 were significantly higher in patients with acute myocardial infarction than the patients in control group （P<0.05）. Serum Gal-3 levels were correlated positively with hs-CRP, MCP-1 and Gensini score （all P<0.05）. Conclusion Serum Gal-3 can predict the degree of coronary lesions in patients with acute myocardial infarction.