载脂蛋白CⅢ的研究现状

The Current Status of Research on Apoprotein CⅢ

摘要:

载脂蛋白CⅢ存在于多种脂蛋白颗粒中,与人类高甘油三酯血症及心血管疾病密切相关,其基因突变造成的保护效应更使得某些特殊人群因心血管病风险降低而获益。除外致动脉粥样硬化作用,该蛋白还具有促炎症反应及细胞凋亡作用,可作为降低心血管病风险新的治疗靶点。文章针对载脂蛋白CⅢ与动脉粥样硬化的关系及其治疗做一综述。

Abstract:

Apoprotein CⅢ exists in a variety of lipoprotein particles and has a close relationship with human hypertriglyceridemia and caidiovascular disease. The protective effects caused by mutations of apoprotein CⅢ genes even result in benefits of lower cardiovascular risk in some particular group of people. Besides its role of atherogenesis, apoprotein CⅢ also promotes inflammatory and apoptosis, which makes it a new therapeutic target for lowering risk of cardiovascular disease. This article mainly summarizes the atherogenesis and therapeutic prospective of aporotein CⅢ.