心房颤动的基因学研究进展

An update on genetic research of atrial fibrillation

摘要:

心房颤动基因学研究包括以下几个于临床有意义的话题:①单/多基因心房颤动的分子遗传变异；②心房颤动的合理分类；③心房颤动家族聚集的遗传学原因；④基因型差异对心房颤动预后的影响及其风险预测；⑤心房颤动的治疗基因学。该文将对以上问题逐一作出论述。

Abstract:

Genetic researches of atrial fibrillation (AF) include the following topics which are important in clinical practice:①the molecular genetic variations of mono/polygenic AF; ②the reasonable classification of AF based on genetics; ③the underlying genetic reasons of its familial segregation; ④the impact of genotype difference on prognosis of patients with AF and AF risk prediction; ⑤the genetic studies on AF treatment. This review is an update on the above-mentioned issues.