巨噬细胞在心肌梗死后的作用研究进展

Research progress on the role of macrophages after myocardial infarction

摘要:

心肌梗死后会在缺血区域引发强烈的炎症反应,各种炎性细胞浸润其中发挥作用。巨噬细胞作为固有免疫反应中重要组成,在心肌损伤后组织修复过程中至关重要。随着心肌梗死的发展,巨噬细胞可以分化成各种亚型,在吞噬凋亡细胞、血管新生、纤维化及瘢痕成熟等各个方面发挥作用。研究巨噬细胞对心肌梗死的影响,有助于探索改善心肌梗死预后及其诊治。本篇综述将围绕心肌梗死后巨噬细胞浸润、极化及功能变化展开讨论。

Abstract:

After myocardial infarction, there will be a strong inflammatory reaction in the ischemic area, in which a variety of inflammatory cells play a role. Macrophages, as an important component of innate immune response, are very important in the process of tissue repair after myocardial injury. With the development of myocardial infarction, macrophages can differentiate into various subtypes and play a role in phagocytosis of apoptotic cells, angiogenesis, fibrosis and scar maturation. To study the influence of macrophages on myocardial infarction is helpful to explore the improvement of prognosis and diagnosis and treatment of myocardial infarction. This review will focus on the infiltration,polarization and functional changes of macrophages after myocardial infarction.