脂肪量和肥胖相关蛋白介导的N6-腺苷酸甲基化在动脉粥样硬化中的研究进展

Advances in fat mass and obesity-related protein-mediated N6-adenylate methylation in atherosclerosis

摘要:

N⁶-腺苷酸甲基化是真核生物中最普遍的mRNA修饰,脂肪量和肥胖相关蛋白是其去甲基化酶,可有效去除mRNA的N⁶-腺苷酸甲基化修饰,与肥胖密切相关。动脉粥样硬化是一种脂质驱动的血管壁慢性炎症性病变。研究发现脂肪量和肥胖相关蛋白介导的N⁶-腺苷酸甲基化可能通过脂代谢、氧化应激、线粒体功能障碍以及巨噬细胞泡沫化影响动脉粥样硬化的进程。

Abstract:

N⁶-methyladenosine (m⁶A) is the most common mRNA modification in eukaryotes, and fat mass and obesity-related protein (FTO), are its demethylases, which efficiently remove the modification of m⁶A mRNA, and is strongly associated with obesity. Atherosclerosis is a chronic inflammatory lesion of the blood vessel wall driven by lipids.It was found that FTO-mediated m⁶A may influence the process of atherosclerosis through lipid metabolism, oxidative stress, mitochondrial dysfunction, and macrophage foaminess.