血管平滑肌细胞表型转化与动脉粥样硬化血管重塑

Atherosclerotic vascular remodeling induced by phenotypic switching of vascular smooth muscle cell

摘要:

动脉粥样硬化是一种慢性血管病变,其早期表现为血管内膜增生和斑块形成,晚期可因斑块受侵蚀后破裂而引发血管事件。动脉粥样硬化进程中,动脉中膜的血管平滑肌细胞(VSMC)扮演着血管重塑的关键角色,其表型转化对维持血管内稳态具有重要影响。囿于方法学限制,既往对VSMC功能的认识有限；随着谱系追踪技术和单细胞测序技术的飞速发展,近年来VSMC在动脉粥样硬化过程中的作用得以深入探索。本文总结了近年来新兴的VSMC的研究方法,并针对VSMC表型转化在血管重塑中的作用和机制进行了综述。

Abstract:

Atherosclerosis is a chronic vascular disease, whose early manifestations are vascular intimal hyperplasia and plaque formation, and the late vascular events can be caused by plaque rupture after erosion. In the process of atherosclerosis, vascular smooth muscle cell(VSMC) in the arterial media play a key role in vascular remodeling, and their phenotype conversion has an important impact on maintaining vascular homeostasis. Due to methodological limitations, the previous understanding of VSMC function is limited; With the rapid development of lineage tracing and single-cell sequencing technology, the role of VSMC in atherosclerosis has been deeply explored in recent years. This paper summarizes the emerging research methods of VSMC in recent years, and reviews the literature on the roles and mechanisms of phenotypic switching of VSMC in vascular remodeling.