组蛋白甲基化修饰与心血管疾病

Association of histone methylation modification with cardiovascular diseases

摘要:

组蛋白甲基化修饰作为翻译后修饰之一,越来越多的研究表明其对心血管疾病(CVD)的发生发展至关重要。由于组蛋白甲基化修饰的可逆性,靶向这些修饰酶被认为可能为CVD的临床诊断和治疗提供新的策略。本文就CVD中相关的甲基化修饰及其重要调控机制进行综述,并探讨了组蛋白甲基化修饰的抑制剂在心血管领域的研究进展。

Abstract:

Histone methylation modification, as one of the post-translational modifications, has been increasingly shown by studies to play a crucial role in the development of cardiovascular diseases (CVD). Due to its reversibility, targeting related modifying enzymes is expected to provide new strategies for the clinical diagnosis and treatment of CVD. This article reviews the relevant methylation modifications and their important regulatory mechanisms in CVD, and discusses the research progress of histone methylation inhibitors in the cardiovascular field.