富含甘油三酯的脂蛋白及其残余物致动脉粥样硬化的机制研究进展

Research progress on the mechanism of atherosclerosis caused by triglyceride-rich lipoprotein and its residues

摘要:

甘油三酯(TG)在血液中以特定的富含甘油三酯的脂蛋白(TRL)的形式进行转运。当TRL产生过量或分解代谢不及时,会形成富含胆固醇酯的残余物,TRL及其残余物通过多种直接或间接机制参与动脉粥样硬化(As)的发生发展。目前,生活方式干预联合西医降脂类药物被认为是As的首选治疗策略。然而,仅靠降脂治疗并不能减少As的残余风险,中医药则着眼于人体整体功能,以达到预防和治疗As的目的。本文将从TRL的代谢机制入手,阐明TRL及其残余物在As发生风险中的作用,并概述当前干预TRL代谢途径减少As发生的方法。

Abstract:

Triglyceride (TG) is transported in the blood as specific triglyceride-rich lipoprotein (TRL). When TRL is overproduced or the catabolism is not timely, cholesterol ester-rich residues is formed. Both TRL and its residues contribute to the development of atherosclerosis (As) through various direct and indirect mechanisms. Currently, the combination of lifestyle interventions and Western medicines is considered the preferred treatment strategy for As. However, lipid-lowering therapy alone cannot fully eliminate the residual risk of As. In contrast, traditional Chinese medicine emphasizes the holistic regulation of bodily functions to prevent and treat As. This paper will begin by examining the metabolic mechanisms of TRL, elucidate the role of TRL and its residues in the risk of As occurrence, and summarize current strategies targeting the TRL metabolic pathway to reduce the incidence of As.