血管周围脂肪组织参与改善心血管疾病的研究进展

Research progress on the involvement of perivascular adipose tissue in improving cardiovascular diseases

摘要:

心血管疾病(CVD)的发病率逐年攀升,其中动脉粥样硬化(As)位居中国CVD发病率和死亡率首位。传统理论认为,动脉粥样硬化性CVD的发病机制与氧化型低密度脂蛋白(ox-LDL)积累导致的内皮功能紊乱和炎症反应有关。然而,最新的研究证明,血管周围脂肪组织(PVAT)能够通过血管外膜途径对CVD的发生与发展产生积极影响。本文对PVAT与CVD的联系、促进CVD改善的有效途径,以及AMP活化蛋白激酶(AMPK)对PVAT的调控作用进行了综述,旨在探索CVD的有效干预靶点。

Abstract:

The incidence of cardiovascular diseases (CVD) has been increasing year by year, with atherosclerosis (As) being the leading cause in terms of both incidnce and mortality for CVD in China. Traditional theories suggest that the pathogenesis of atherosclerotic CVD is associated with endothelial dysfunction and inflammatory responses caused by the accumulation of oxidized low density lipoprotein (ox-LDL). However, recent studies have demonstrated that perivascular adipose tissue (PVAT) can positively influence the occurrence and development of CVD through the vascular adventitia pathway. This article reviews the connection between PVAT and CVD, effective pathways for promoting CVD improvement, and the regulatory role of AMP-activated protein kinase (AMPK) on PVAT, aiming to explore effective intervention targets for CVD.