昼夜节律和时钟基因在动脉粥样硬化发生中的作用机制研究进展

The progress of the role and mechanisms of circadian rhythm and clock gene in the development of atherosclerosis

摘要:

随着全球人口寿命的延长和老龄化问题的日益严峻,心血管疾病已经成为老龄化人群的主要死亡原因。心血管疾病大多起源于动脉粥样硬化斑块的形成。除了常见的危险因素,如血脂异常、糖尿病、高血压、吸烟和肥胖外,昼夜节律的紊乱也被视为动脉粥样硬化的一个重要但常被忽视的危险因素。昼夜节律参与调节炎症和代谢等关键生理过程,进而影响动脉硬化和血栓形成的病理过程。在这一过程中,维持昼夜节律稳定的关键基因,即时钟基因,扮演着至关重要的角色。时钟基因在动脉粥样硬化的病理机制中具有重要作用,它们有可能成为预防和治疗动脉粥样硬化的潜在新靶点。本文综述了时钟基因在动脉粥样硬化发生和发展中的作用机制的最新研究进展,这些发现可能为动脉粥样硬化的诊断和治疗提供新的思路。

Abstract:

With the extension of the global population's lifespan and the increasingly severe aging problem, cardiovascular diseases have become the leading cause of death among the elderly population. Most cardiovascular diseases originate from the formation of atherosclerotic plaques. In addition to common risk factors such as dyslipidemia, diabetes, hypertension, smoking, and obesity, circadian rhythm disruption is also regarded as an important but often overlooked risk factor for atherosclerosis. The circadian rhythm is involved in regulating key physiological processes such as inflammation and metabolism, which in turn affect the pathological processes of arteriosclerosis and thrombosis. In this process, the key genes that maintain the stability of the circadian rhythm, namely clock gene, play a crucial role. Clock gene have an important role in the pathological mechanism of atherosclerosis, and they may become potential new targets for the prevention and treatment of atherosclerosis. This paper reviews the latest research progress on the mechanism of action of clock gene in the occurrence and development of atherosclerosis. These findings may provide new ideas for the diagnosis and treatment of atherosclerosis.