典型持久性有机污染物对动脉粥样硬化的影响

Effects of typical persistentorganic pollutants on atherosclerosis

摘要:

心血管疾病是全球范围内严重的健康负担之一,动脉粥样硬化是其重要的病理基础。近年来,环境污染物对人类健康的影响逐渐受到关注。一些新的流行病学研究调查和实验表明,持久性有机污染物可促进动脉粥样硬化的发生发展,是心血管疾病的独立危险因素。持久性有机污染物影响动脉粥样硬化的主要作用机制与氧化应激、细胞表型转化、血脂紊乱、基因改变等有关。该文就多氯联苯、全氟及多氟烷基化学物等典型持久性有机污染物对动脉粥样硬化的最新流行病学研究调查和实验进行综合阐述,以期为今后的相关研究提供参考。

Abstract:

Cardiovascular disease is one of the serious health burdens in the world, and atherosclerosis is its important pathological basis. In recent years, the effect of environmental pollutants on human health has been paid more and more attention. Some new epidemiological studies and experiments have reported that environmental organic pollutants, involved in the occurrence and development of atherosclerosis, is an independent risk factor of cardiovascular diseases. Evidence shows that it is related to oxidative stress response, cell phenotype transformation, dyslipidemia, genetic changes and so on. This review summarizes available studies on the latest epidemiological studies and experiments of typical persistent organic pollutants such as polychlorinated biphenyls and per- and polyfluoroalkyl substances so as to provide references for future research.