传统中药作为PPAR调节剂在动脉粥样硬化治疗中的应用

Application of traditional Chinese medicine for treatment of atherosclerosis via targeting PPAR

摘要:

动脉粥样硬化被认为是一种慢性炎症病变,其发展进程受诸多因素的影响,特别是脂代谢失衡。过氧化物酶体增殖物激活受体(PPAR)参与调控脂质代谢和炎症相关基因的表达,其包括三个亚型,即PPARα、PPARβ和PPARγ。然而,人工合成的PPAR激动剂在动脉粥样硬化防治中的表现存在不确定性,且具有多种毒副作用。近年研究表明,传统中药(TCM)可通过调节PPAR信号通路缓解高脂血症和炎症反应,在防治动脉粥样硬化性心血管疾病方面取得了良好疗效。本文对近年来有关TCM调控PPAR进而缓解动脉粥样硬化的相关研究进行综述,旨在为致力于探索TCM治疗动脉粥样硬化有效方案的药理学家,以及热衷于应用TCM防治动脉粥样硬化性心血管疾病的临床医师提供坚实的理论依据。

Abstract:

Atherosclerosis is recognized as an inflammatory disease, and its development is regulated by multiple factors, particularly dyslipidemia. Peroxisome proliferator-activated receptor (PPAR) regulate the expression of genes that are involved in lipid metabolism and inflammation; and they have three subfamily members including PPARα, PPARβ, and PPARγ. However, synthetic PPAR agonists exhibit ambiguous effects in atherosclerotic therapy and induce various side effects. Notably, recent studies demonstrate that traditional Chinese medicine (TCM) alleviate atherosclerotic cardiovascular diseases via suppressing hyperlipidemia and inflammation through regulation of PPAR signaling pathway. This article primarily reviews the regulatory effects of TCM on PPAR and their therapeutic effects on atherosclerosis, provides valuable information for pharmacologists that are interested in searching for effective herbal prescriptions for atherosclerosis therapy and for clinicians that are interested in prevention and treatment of atherosclerotic cardiovascular diseases using TCM.