乳酸化修饰在心血管疾病发病机制中的作用

The role of lactylation modification in the pathogenesis of cardiovascular diseases

摘要:

心血管疾病(CVD)是一类由遗传及环境因素相互作用所致的常见复杂性疾病,与表观遗传修饰关系密切。新近研究发现,乳酸化修饰作为一种新发现的表观遗传修饰,可通过向赖氨酸残基中添加乳酰基来调节组蛋白,以促进特异性基因转录和表达。此外,乳酸化修饰还可以影响非组蛋白的结构和功能,在动脉粥样硬化(As)、心肌梗死(MI)、缺血再灌注损伤(IRI)和心力衰竭(HF)等CVD发病机制中发挥重要作用。笔者梳理近年来发表的乳酸化修饰在CVD中作用的相关文献并进行总结阐述,以期为未来的研究提供参考。

Abstract:

Cardiovascular diseases (CVD) are common complex diseases caused by the interaction of genetic and environmental factors and are closely related to epigenetic modifications. Recent studies have found that lactylation modification, a newly discovered epigenetic mechanism, regulates histones by adding lactyl groups to lysine residues, thereby promoting the transcription and expression of specific genes. Moreover, it also affects the structure and function of non-histone proteins and plays important roles in the pathogenesis of CVD such as atherosclerosis (As), myocardial infarction (MI), ischemia reperfusion injury (IRI)and heart failure (HF) by regulating protein function and gene expression. In this review, the author summarizes and elaborates on the relevant literature on the roles of lactylation modification in CVD published in recent years, in order to provide reference for future research.