转录因子SOX9在心血管系统中的作用研究进展

Research progress on the role of transcription factor SOX9 in cardiovascular system

摘要:

心血管疾病是影响全球人类健康的重要问题,其发病率呈逐年上升趋势。近年来,越来越多的研究表明,Y染色体性别决定区(SRY)相关高迁移率组盒蛋白9(SOX9)作为具有高度保守性的转录因子,在基因转录水平上广泛地参与调控心脏发育和心血管系统疾病进展过程。SOX9可单独或联合其他蛋白质,与下游靶基因启动子区域的对应顺式作用元件结合,参与调控心脏发育下游或心血管疾病相关基因的表达。因此,SOX9有可能成为心血管系统新型治疗靶点。本文以SOX9为切入点,系统叙述其结构与功能,并概述SOX9在心脏重构和血管重塑中的最新研究进展,以期为未来预防和治疗心血管系统疾病提供新的思路和方法。

Abstract:

Cardiovascular disease is an important problem affecting global human health, and its incidence is increasing year by year. In recent years, more and more studies have shown that sex-determined region of Y (SRY)-related high mobility group-box 9 (SOX9) gene, as a highly conserved transcription factor, is widely involved in regulating cardiac dvelopment and cardiovascular disease progression at the level of gene transcription. SOX9, alone or in combination with other proteins, can bind to corresponding cis-acting elements in the downstream target gene promoter region and participate in regulating the expression of downstream heart development or cardiovascular disease-related genes. Therefore, SOX9 has the potential to be a new therapeutic target for the cardiovascular system. In this paper, the structure and function of SOX9 were systematically described, and the latest research progress of SOX9 in cardiac remodeling and vascular remodeling was summarized, in order to provide new ideas and methods for the prevention and treatment of cardiovascular system diseases in the future.