脂代谢紊乱与血管衰老研究进展

Advance in lipid metabolism disorder and vascular aging

摘要:

分析脂代谢紊乱通过血管内皮细胞、血管平滑肌细胞以及巨噬细胞引起血管衰老的作用与机制。脂代谢紊乱通过活性氧(ROS)通路、内皮型一氧化氮合酶(eNOS)活性、氧化型低密度脂蛋白(ox-LDL)、炎症小体及多种炎症因子等损害内皮细胞促进血管衰老。脂代谢紊乱通过血管平滑肌细胞自噬、DNA损伤及核因子κB(NF-κB)等途径加速血管衰老进程。脂代谢紊乱刺激血管壁内巨噬细胞分泌多种炎症因子作用于Toll样受体(TLR)途径、促进氧化应激引起DNA损伤,从而促进血管衰老。脂代谢紊乱促进血管内皮细胞、血管平滑肌细胞及巨噬细胞氧化应激与慢性炎症等,从而导致血管衰老。

Abstract:

To analyse the role and mechanism of lipid metabolism disorder in vascular aging caused by endothelial cells, smooth muscle cells, and macrophages. Lipid metabolism disorder damages endothelial cells and promotes vascular aging through the reactive oxygen species (ROS) pathway, endothelial nitric oxide synthase (eNOS) activity, oxidized low density lipoprotein (ox-LDL), inflammasomes, and various inflammatory factors. Lipid metabolism disorder accelerates vascular aging process through autophagy, DNA damage, and nuclear factor-κB (NF-κB) in vascular smooth muscle cells.Lipid metabolism disorder stimulates macrophages in the vascular wall to secrete various inflammatory factors that act on the Toll-like receptor (TLR) pathway, promoting oxidative stress and causing DNA damage, thereby promoting vascular aging.Lipid metabolism disorder promotes oxidative stress and chronic inflammation in endothelial cells, smooth muscle cells, and macrophages, leading to vascular aging.