代谢重编程在主动脉夹层中的研究进展

Research progress on metabolic reprogramming in aortic dissection

摘要:

主动脉夹层(AD)是一种危及生命的急性血管疾病,其发病机制复杂且尚未完全明了。近年来,代谢重编程在AD的发生和发展中逐渐显现出重要作用。本文综述了氨基酸代谢、糖代谢和脂代谢等主要代谢途径在AD中的异常变化及其对血管细胞功能的影响。代谢重编程通过调控内皮细胞(EC)和血管平滑肌细胞(VSMC)的功能,促进血管壁结构的破坏和炎症反应的加剧,进而推动AD的发展。此外,本文还总结了代谢相关分子在AD早期诊断和治疗中的潜在应用,强调了代谢调控作为AD防治新策略的重要性。最后,提出了代谢重编程在AD研究中的未来方向,包括深入机制研究、开发新型生物标志物以及优化临床干预策略,以期为AD的预防和治疗提供新的思路和方法。

Abstract:

Aortic dissection (AD) is a life-threatening acute vascular disease with a complex and not yet fully understood pathogenesis. In recent years, metabolic reprogramming has gradually emerged as a significant factor in the occurrence and development of AD. This review summarizes the abnormal alterations in major metabolic pathways, including amino acid metabolism, glucose metabolism, and lipid metabolism, and their impact on vascular cell functions in AD. Metabolic reprogramming contributes to the progression of AD by regulating the functions of endothelial cells (EC) and vascular smooth muscle cells (VSMC), thereby promoting the destruction of the vascular wall structure and exacerbating inflammatory responses. Additionally, this paper summarizes the potential applications of metabolism-related molecules in the early diagnosis and treatment of AD, emphasizing the importance of metabolic regulation as a novel strategy for AD prevention and management. Finally, future research directions in the study of metabolic reprogramming in AD are proposed, including in-depth mechanistic studies, the development of novel biomarkers, and the optimization of clinical intervention strategies, aiming to provide new insights and methods for the prevention and treatment of AD.