环境因子诱导产生的活性氧对载脂蛋白的修饰作用在动脉粥样硬化中的研究进展

Progress in the role of reactive oxygen species induced by environmental factors on apolipoproteins in atherosclerosis

摘要:

空气污染物、塑料微粒、电离辐射及交通噪声等环境因子,通过诱发炎症反应、促进氧化应激和加速脂质沉积等机制,促进动脉粥样硬化性心血管疾病(CVD)的发生与发展。其中,活性氧(ROS)对载脂蛋白(Apo)的修饰作用加速了这一进程。一方面,ROS可氧化Apo中的关键氨基酸残基,改变其结构,进而影响其正常生理功能；另一方面,ROS能诱导Apo发生脂质过氧化反应,使氧化修饰后的Apo更易被巨噬细胞识别与摄取,从而加速泡沫细胞形成,推动动脉粥样硬化(As)斑块的进展。本文综述了环境因子诱导产生的ROS对Apo的修饰作用在动脉粥样硬化性CVD中的研究进展。

Abstract:

Environmental factors such as air pollutants, plastic micro-particles, ionizing radiation, and traffic noise promote the onset and progression of atherosclerotic cardiovascular disease(CVD)through mechanisms including inducing inflammatory responses, promoting oxidative stress, and accelerating lipid deposition. Notably, the modification of apolipoprotein (Apo) by reactive oxygen species (ROS) accelerates this process. On one hand, ROS can oxidize key amino acid residues in Apo, altering its structure and thereby impairing its normal physiological function. On the other hand, ROS can induce lipid peroxidation of Apo, rendering the oxidized Apo more susceptible to recognition and uptake by macrophages. This accelerates foam cell formation and drives the progression of atherosclerotic (As) plaques. This review summarizes recent research advances on the role of ROS-induced modification of Apo by environmental factors in atherosclerotic CVD.