可溶性鸟苷酸环化酶激动剂在动脉粥样硬化性疾病中的研究进展

Research progress of soluble guanylate cyclase agonists in atherosclerotic diseases

摘要:

动脉粥样硬化是一种慢性炎症性疾病,是大多数心血管疾病的根本原因。可溶性鸟苷酸环化酶(sGC)激动剂在一氧化氮(NO)/sGC/环磷酸鸟苷(cGMP)信号通路调节动脉粥样硬化性疾病方面起着重要作用。sGC激动剂通过活化下游的cGMP,发挥降低血脂水平、改善内皮功能障碍、减少炎症反应、抑制血小板活化、抑制平滑肌细胞增殖和抗细胞凋亡等抗动脉粥样硬化作用。该文综述了sGC激动剂对抗动脉粥样硬化的影响及其作用机制,旨在为sGC激动剂的临床应用提供理论依据。

Abstract:

Atherosclerosis is a chronic inflammatory disease and the root cause of most cardiovascular diseases. Soluble guanylate cyclase (sGC) agonists play an important role in the regulation of atherosclerotic diseases by nitric oxide (NO)/sGC/cyclic guanosine phosphate (cGMP) signaling pathway. sGC plays an anti-atherosclerotic role in reducing blood lipid levels, improving endothelial dysfunction, reducing inflammatory responses, inhibiting platelet activation, inhibiting smooth muscle cell proliferation and apoptosis via activating downstream cGMP. This article reviews the effect of sGC agonists on atherosclerosis and its mechanism, in order to provide a theoretical basis for the clinical application of sGC agonists.