乳酸及乳酸化修饰在心血管疾病中的研究进展

Research progress of lactate and lactylation in cardiovascular diseases

摘要:

代谢重编程在心血管疾病(CVD)的发病机制中发挥着关键作用。乳酸是糖酵解的代谢物,现已被视为一种重要的细胞信号分子,参与调控微环境中的多种代谢过程。新近发现的乳酸化修饰,在动脉粥样硬化(As)、血管或瓣膜钙化、心肌梗死、心力衰竭(HF)和肺动脉高压(PH)等CVD中发挥重要作用。该文综述了乳酸和乳酸化修饰在上述CVD中的调控机制,旨在为其精准防治策略提供新的思路。

Abstract:

Metabolic reprogramming plays a crucial role in the pathogenesis of cardiovascular diseases (CVD). Lactate, a metabolite of glycolysis, is now considered an important cellular signaling molecule involved in regulating various metabolic processes within the microenvironment. Recently discovered lactylation modifications have been found to play significant roles in CVD such as atherosclerosis (As), vascular or valve calcification, myocardial infarction, heart failure (HF), and pulmonary hypertension (PH). This review summarizes the regulatory mechanisms of lactate and lactylation modifications in these CVD, aiming to provide new insights for their precise prevention and treatment strategies.