动脉粥样硬化中抗内皮功能障碍的治疗进展

Progress in the treatment of endothelial dysfunction in atherosclerosis

摘要:

动脉粥样硬化是一种慢性血管壁病变,临床表现为受累动脉病变处的内膜下出现异常的脂质沉积、纤维组织增生及钙质沉着等,其起始环节与内皮功能障碍有关,可由不同的动脉粥样硬化危险因素触发和加重,包括氧化应激、血流动力学异常、内皮细胞衰老和炎症等。探索内皮功能障碍的机制有利于发现动脉粥样硬化的潜在治疗手段。本文总结了针对动脉粥样硬化中内皮功能障碍的药物治疗机制与研究进展。

Abstract:

Atherosclerosis is a chronic vascular wall disease. The clinical manifestations are abnormal lipid deposition, fibrous hyperplasia, calcium deposition, etc. under the intima of the affected artery lesions. Its initial link is related to endothelial cell dysfunction, which can be triggered and aggravated by different risk factors of atherosclerosis, including oxidative stress, hemodynamic abnormalities, endothelial cell senescence and inflammation, etc. Exploring the mechanism of endothelial cell dysfunction is conducive to the discovery of potential treatments for atherosclerosis. This article summarizes the mechanism and research progress of drug therapy for endothelial cell dysfunction in atherosclerosis.