EGCG在动脉粥样硬化防治中的作用机制及展望

Mechanisms and Prospects of EGCG in the Prevention and Treatment of Atherosclerosis

摘要:

动脉粥样硬化(As)是一种慢性炎症性血管病变,是多种心血管疾病的病理基础。表没食子儿茶素没食子酸酯(EGCG)是绿茶中含量最丰富且生物活性最强的化合物,具有抗炎、抗病毒和抑制氧化应激等多种药理作用。近年来研究发现,EGCG能够调节脂质代谢、改善血管内皮功能并增强斑块稳定性,显示出抗As的潜在价值。本文系统综述了EGCG抗As的作用机制,以期为该化合物在As防治领域的深入研究和临床应用提供多角度的理论依据。

Abstract:

Atherosclerosis (As) is a chronic inflammatory vascular disease and serves as the pathological basis for various cardiovascular diseases. Epigallocatechin-3-O-gallate (EGCG) is the most abundant and biologically active compound in green tea, possessing multiple pharmacological effects such as anti-inflammatory, antiviral, and antioxidative stress properties. In recent years, studies have found that EGCG can regulate lipid metabolism, improve vascular endothelial function, and enhance plaque stability, demonstrating its potential value in combating As. This article provides a systematic review of the mechanisms underlying EGCG’s anti-As effects, aiming to offer multi-faceted theoretical support for its further research and clinical application in the prevention and treatment of As.