应激性高血糖比值与缺血性心脏病相关研究进展

Research advances on the correlation between stress hyperglycemia ratio and ischemic heart disease

摘要:

缺血性心脏病是以心脏血流量减少、心肌需氧和供氧失衡为特征的临床疾病。既往研究表明应激性高血糖与急性心肌梗死、心力衰竭患者死亡率增加相关,是缺血性心脏病不良预后危险因素。应激性高血糖比值是根据入院随机血糖与糖化血红蛋白通过数学模型计算所得的数值,是一种可以更准确评估应激性高血糖的新指标。近期研究发现,应激性高血糖比值与冠状动脉疾病、急性心肌梗死及缺血性心脏病导致的心力衰竭密切相关。文章从三个方面综述了应激性高血糖比值与缺血性心脏病的相关研究进展,应激性高血糖比值有可能作为缺血性心脏病疾病危险分层、评估预后的生物化学指标。

Abstract:

Ischemic heart disease (IHD) is a clinical disease characterized by reduced cardiac blood flow and imbalanced myocardial oxygen supply-demand. Previous studies have shown that stress hyperglycemia is associated with increased mortality in patients with acute myocardial infarction and heart failure, and is a poor prognostic risk factor for ischemic heart disease. Stress hyperglycemia ratio (SHR) is a value calculated based on the random blood glucose and glycated hemoglobin levels at admission through a mathematical model. As a novel indicator, it enables more accurate assessment of stress hyperglycemia. Recent studies has found that SHR is closely related to coronary artery disease, acute myocardial infarction, and heart failure caused by IHD. This article reviews the research progress on the association between SHR and IHD from three aspects. SHR may serve as a biochemical marker for risk stratification, prognosis assessment of IHD.