动脉粥样硬化生物标志物的研究进展

Research progress of atherosclerosis biomarkers

摘要:

动脉粥样硬化及其并发症是全球发病率和死亡率最高的疾病之一,其早期的诊断和治疗十分重要。目前,多种生理学和生物化学指标已被应用于诊断动脉粥样硬化。然而,现有诊断指标的准确性、易用性仍然不能满足临床需要,新的、早期诊断和判断动脉粥样硬化及其导致的严重心脑血管事件风险的可靠、易测量的生物标志物仍然非常缺乏。该文总结了动脉粥样硬化相关的血液学、遗传学和组学等生物标志物的最新研究进展,以期为动脉粥样硬化及其诱导的相关心脑血管疾病的早期诊断和治疗提供依据。

Abstract:

Atherosclerosis and its complications are one of the diseases with the highest incidence and mortality in the world, and its early diagnosis and treatment are very important. At present, a variety of physiological and biochemical indicators have been used to diagnose atherosclerosis. However, the accuracy and ease of use of existing diagnostic indicators still cannot meet the clinical needs, and new, reliable and easy to measure biomarkers for early diagnosis and judgment of atherosclerosis and the risk of serious cardiovascular and cerebrovascular events caused by atherosclerosis are still very scarce. This article summarized the latest research progress of biomarkers related to atherosclerosis, such as hematology, genetics and omics, in order to provide basis for early diagnosis and treatment of atherosclerosis and related cardiovascular and cerebrovascular diseases induced by atherosclerosis.