胸腺素β4在急性心肌梗死发病机制及治疗研究中的进展

Research progress of thymosin β4 in the pathogenesis and treatment of acute myocardial infarction

摘要:

急性心肌梗死对现代社会的健康和经济仍然存在较大危害。目前的研究表明,胸腺素β4(Tβ4)能够促进心外膜激活,通过减少心肌细胞凋亡、促进细胞存活和迁移,从而保护心肌细胞,有效抑制由心肌梗死引发的炎症反应和纤维化。此外,Tβ4还能诱导新生血管生成,改善心肌血供。本文对Tβ4在急性心肌梗死发病机制及治疗研究中的进展进行综述。

Abstract:

Acute myocardial infarction still does great harm to the health and economy of modern society. Current studies have shown that thymosin β4 (Tβ4) can promote epicardial activation, protect cardiomyocytes by reducing apoptosis, promoting survival and migration, and inhibit the inflammatory response and fibrosis caused by myocardial infarction.Furthermore, it can induce neovascularization and improve mycardial blood supply. This article reviews the research progress of Tβ4 in the pathogenesis and treatment of acute myocardial infarction.