心血管疾病的血管生成及巨噬细胞调控策略

Strategies for modulating angiogenesis and macrophage function in cardiovascular diseases

摘要:

血管生成是心脏缺血性损伤治疗中的关键过程,巨噬细胞在其中发挥重要作用。本文综述了巨噬细胞通过分泌关键因子及与其他细胞相互作用调节血管生成的研究进展。M1型巨噬细胞在早期通过分泌促血管生成因子促进血管生成,而M2型巨噬细胞则主要在血管重塑和稳态维持中发挥作用。本文还探讨了几种新的促血管生成策略,包括直接注射巨噬细胞、调节巨噬细胞表型及功能,以及利用巨噬细胞来源的外泌体。大量研究表明,巨噬细胞在血管生成中具有多重功能,靶向巨噬细胞为促进血管生成和治疗缺血性疾病提供了新的治疗靶点和方向。

Abstract:

Angiogenesis is a critical process in the treatment of cardiac ischemic injury, and numerous research findings indicate that macrophages play a vital role in angiogenesis. This review summarizes how macrophages regulate angiogenesis through the secretion of key factors and the interactions with other cells. M1 macrophages promote new blood vessel formation in the early stages by secreting pro-angiogenic factors, while M2 macrophages are involved in vascular remodeling and maintaining vessel homeostasis. This review also discusses several new therapeutic strategies for promoting angiogenesis, including direct injection of macrophages, modulation of macrophage phenotype and function, and the use of macrophage-derived exosomes. Numerous studies have shown that macrophages have multiple functions in angiogenesis, and targeting macrophages provides new therapeutic targets and directions for promoting angiogenesis and treating ischemic diseases.