2型糖尿病周围神经病变患者标准化F波潜伏期与颈动脉内膜中膜厚度的相关性

Correlation between standardized F-wave latency and carotid intima-media thickness in type 2 diabetes mellitus patients with peripheral neuropathy

摘要:

目的]探究2型糖尿病(T2DM)周围神经病变(DPN)患者标准化F波潜伏期与颈动脉内膜中膜厚度(CIMT)的相关性。 [方法]选择2022年3月—2023年5月在本院就诊的DPN患者120例为研究对象,按CIMT分为增厚组(n＝57)与未增厚组(n＝63)。比较两组患者的一般资料及标准化F波潜伏期,采用多元线性回归分析标准化F波潜伏期与CIMT的关系。采用限制性立方样条模型分析标准化F波潜伏期与CIMT增厚风险的剂量-反应关系,采用ROC曲线分析标准化F波潜伏期对CIMT增厚的预测价值。依据DPN程度分为重度组(n＝42)和非重度组(n＝78),采用多因素Logistic回归分析重度DPN的危险因素,对不同CIMT重度DPN情况进行亚组分析。 [结果]增厚组的标准化F波潜伏期的最小值、平均值和最大值均高于未增厚组,两组间差异有统计学意义(P＜0.05)。标准化F波潜伏期的最小值、平均值和最大值与CIMT增厚风险存在非线性剂量-反应关系(P＜0.05),随着标准化F波潜伏期的最小值、平均值和最大值升高,CIMT增厚风险增加,呈正相关(P＜0.05)。T2DM病程长、标准化F波潜伏期延长是重度DPN的潜在危险因素(P＜0.05)。增厚组的总体DPN程度更重,重度DPN更多发生在标准化F波潜伏期最小值≥13.12 ms者、平均值≥17.04 ms者、最大值≥19.35 ms者。标准化F波潜伏期的最小值、平均值、最大值升高对CIMT增厚具有良好的预测价值。 [结论]DPN患者的标准化F波潜伏期与CIMT密切相关,随着标准化F波潜伏期的最小值、平均值和最大值升高,CIMT增厚风险增加,且共同影响DPN的病情程度。

Abstract:

Aim To explore the correlation between the standardized F wave latency and the carotid intima-media thickness (CIMT) in patients with type 2 diabetes mellitus (T2DM) peripheral neuropathy (DPN). Methods120 DPN patients who visited our hospital from March 2022 to May 2023 were selected as the study subjects, and were divided into thickened group (n＝57) and non-thickened group (n＝63) based on CIMT. The general information and standardized F-wave latency of two groups of patients were compared, and multivariate linear regression analysis was used to investigate the relationship between standardized F-wave latency and CIMT. Restricted cubic spline model was used to analyze the dose-response relationship between standardized F-wave latency and CIMT thickening risk, and ROC curve was used to analyze the predictive value of standardized F-wave latency for CIMT thickening. According to the degree of DPN, the patients were divided into severe group (n＝42) and non severe group (n＝78). Multivariate Logistic regression was used to analyze the risk factors of severe DPN, and subgroup analysis was conducted on severe DPN in different CIMT. Results The minimum, average, and maximum values of standardized F-wave latency were higher in the thickened group than those in the non-thickened group, and the difference between the two groups was statistically significant (P＜0.05). There was a non-linear dose-response relationship between the minimum, average, and maximum values of standardized F-wave latency and the risk of CIMT thickening (P＜0.05). As the minimum, average, and maximum values of standardized F-wave latency increased, the risk of CIMT thickening increased. The minimum, average, and maximum values of standardized F-wave latency were positively correlated with CIMT (P＜0.05). Long duration of T2DM and elevated standardized F-wave latency were independent risk factors for severe DPN (P＜0.05). The overall DPN severity was more severe in the thickened group, and severe DPN occured more frequently in individuals with a minimum standardized F-wave latency ≥13.12 ms, a mean standardized F-wave latency ≥17.04 ms, or a maximum standardized F-wave latency ≥19.35 ms. The minimum, average, and maximum values of standardized F-wave latency had good predictive value for CIMT thickening. Conclusion The standardized F-wave latency of DPN is closely related to CIMT. As the minimum, average, and maximum values of standardized F-wave latency increase, the risk of CIMT thickening increases, and together they affect the severity of DPN.