MHR、TyG水平与冠状动脉原位狭窄病变药物涂层球囊治疗后再狭窄的关联

Correlation between MHR, TyG levels and restenosis after drug-coated balloon therapy for coronary artery in-situ stenosis lesions

摘要:

目的]探索单核细胞/高密度脂蛋白比值(MHR)和甘油三酯葡萄糖指数(TyG)与冠状动脉原位狭窄病变行药物涂层球囊治疗后发生再狭窄的关联性。 [方法]纳入2022年1月—2024年12月行药物涂层球囊扩张术,并再次复查冠状动脉造影的患者共115例。根据复查造影结果分为未狭窄组(59例)和再狭窄组(56例),单因素/多因素回归分析、相关性分析和ROC曲线分析评估MHR、TyG对再狭窄发生的影响和预测价值。 [结果]相较于未狭窄组,再狭窄组在糖尿病患者占比、单核细胞数、空腹血糖、甘油三酯、低密度脂蛋白胆固醇、脂蛋白(a)、MHR和TyG方面均显著增加(P＜0.05)。Logistic回归分析显示MHR、TyG水平升高是药物涂层球囊治疗后再狭窄发生的独立危险因素,且MHR、TyG水平与药物涂层球囊治疗后再狭窄发生呈正相关。ROC曲线分析显示MHR、TyG水平对药物涂层球囊治疗后再狭窄的发生有较好的预测效能,且其联合应用的预测效能进一步提升。 [结论]MHR、TyG水平升高与冠状动脉原位狭窄病变药物涂层球囊治疗后再狭窄发生风险存在显著关联,是有效预测再狭窄发生的潜在指标。

Abstract:

Aim To explore the relationship between monocyte-to-high density lipoprotein ratio (MHR), triglyceride-glucose index (TyG) and restenosis after drug-coated balloon therapy for coronary artery in-situ stenosis lesions. Methods From January 2022 to December 4,5 patients who underwent drug-coated balloon dilatation and subsequent coronary angiography re-examination were included. According to the results of re-examination, they were divided into non-stenosis group (59 cases) and restenosis group (56 cases). Univariate/multivariate regression analysis, correlation analysis and ROC curve analysis were used to evaluate the effect and predictive value of MHR and TyG on the occurrence of restenosis. Results Compared with the non-stenosis group, the proportion of diabetic patients, monocyte count, fasting blood glucose, triglyceride, low density lipoprotein cholesterol, lipoprotein (a), MHR and TyG were significantly increased in the restenosis group (P＜0.05). Logistic regression analysis showed that elevated levels of MHR and TyG were independent risk factors for restenosis after drug-coated balloon dilatation. Moreover, MHR and TyG were positively correlated with the occurrence of restenosis after drug-coated balloon therapy. ROC curve analysis showed that MHR and TyG had good predictive value for restenosis after drug-coated balloon therapy, and the predictive value of their combined use was further enhanced. Conclusion The elevated levels of MHR and TyG are significantly correlated with the risk of restenosis after drug-coated balloon therapy for in-situ coronary stenosis, and they serve as potential indicators for effectively predicting the occurrence of restenosis.