血管钙化相关microRNA研究进展

Research progress of microRNA related to vascular calcification

摘要:

血管钙化是多种疾病的病理基础,主要机制是钙磷的异常沉积。微小核糖核酸(miRNA)是一类短小的非编码RNA分子,参与基因的转录与翻译过程。研究发现,在高磷、高糖环境或慢性肾脏病的病理条件下,miRNA的表达会出现变化。这些变化通过不同的信号通路,影响血管平滑肌细胞的成骨化转变以及成骨标志物的表达,进而促进或抑制血管钙化的进程。miRNA有望成为治疗血管钙化的靶点或者反映血管钙化水平的标志物。本文旨在总结miRNA调控血管钙化的机制通路和相关成果,为miRNA和血管钙化研究提供参考。

Abstract:

Vascular calcification is the pathological basis of multiple diseases, and its main mechanism is the abnormal deposition of calcium and phosphorus. MicroRNAs (miRNA) are a class of short non-coding RNA molecules that participate in the processes of gene transcription and translation. Studies have shown that miRNA expression is altered under pathological conditions such as hyperphosphatemia, hyperglycemia, or chronic kidney disease. These alterations, via different signaling pathways, affect the osteogenic transdifferentiation of vascular smooth muscle cells and the expression of osteogenic markers, and thus promote or inhibit the progression of vascular calcification. miRNA hold promise as therapeutic targets for vascular calcification or biomarkers reflecting the level of vascular calcification. This paper aims to summarize the mechanism pathways and relevant achievements of miRNA in regulating vascular calcification, providing a reference for the research on miRNA and vascular calcification.