免疫细胞异质性调控心肌梗死后心室重塑:从单细胞解析到精准治疗

Immune cell heterogeneity regulates ventricular remodeling after myocardial infarction:from single-cell resolution to precision therapy

摘要:

心肌梗死后心室重塑可引发心力衰竭并导致不良预后,其机制主要涉及免疫细胞的动态调控与微环境的相互作用,但免疫细胞亚群的动态演变过程及功能多样性仍有待进一步研究。单细胞测序技术的发展揭示了免疫细胞亚群在损伤不同阶段呈现的功能多样性,这些亚群通过细胞间互作、代谢重编程与信号通路调控等核心机制,决定着炎症消退与组织修复的最终结局。未来仍需整合空间多组学、纳米递送等先进技术,以突破转化瓶颈。本文全面总结了关键免疫细胞亚群在心肌梗死后心室重塑中的作用及其分子机制,并对靶向免疫调控的治疗策略展开了探讨。

Abstract:

Post-myocardial infarction ventricular remodeling can lead to heart failure and poor outcomes, and its mechanisms mainly involve dynamic regulation of immune cells and their interactions with the microenvironment. However, the dynamic evolutionary process and functional diversity of immune cell subpopulations still require further investigation. The development of Single-cell sequencing technology has revealed the functional diversity exhibited by immune cell subpopulations at different stages of injury. These subpopulations crucially determine the final outcomes of inflammation resolution and tissue repair through core mechanisms such as cell-cell interactions, metabolic reprogramming, and signaling pathways regulation. In the future, it is still necessary to integrate advanced technologies such as spatial multiomics and nanodelivery to overcome translational bottlenecks. This article comprehensively summarizes the roles of key immune cell subpopulations and their molecular mechanisms in ventricular remodeling after myocardial infarction, and discusses therapeutic strategies for targeted immune regulation. 〖JP