山奈酚抗动脉粥样硬化的作用机制研究进展

Research progress on the mechanism of kaempferol against atherosclerosis

摘要:

动脉粥样硬化(As)是心血管系统中的一种常见疾病,其特征是血管内膜形成粥样斑块或纤维斑块,导致血管壁硬化、管腔狭窄及弹性下降,从而引发相应器官的缺血性病变。山奈酚是一种存在于多种植物和水果中的天然黄酮类化合物,具有显著的抗炎和抗氧化特性。由于传统降脂疗法存在一定的局限性,近年来,具有抗As活性且有益于人类健康的天然产物日益受到关注。已有研究证实山奈酚在抗As方面的分子机制。本文结合国内外最新研究进展,系统综述山奈酚在抗炎、抗氧化和抗As方面的作用,阐明其潜在的作用机制,以期为As的预防和治疗提供理论参考。

Abstract:

Atherosclerosis (As) is a common disease in the cardiovascular system, characterized by the formation of atherosclerotic plaques or fibrous plaques in the vascular intima, leading to vessel wall hardening, lumen stenosis, and reduced elasticity, thereby causing ischemic changes in corresponding organs. Kaempferol is a natural flavonoid compound found in various plants and fruits, possessing significant anti-inflammatory and antioxidant properties. Due to the limitations of traditional lipid-lowering therapies, natural products with anti-As activity and potential benefits for human health have garnered increasing attention in recent years. The molecular mechanisms of kaempferol in combating As have been confirmed. Based on the latest research advances domestically and internationally, this article systematically reviews the anti-inflammatory, antioxidant, and anti-As effects of kaempferol, elucidates its potential mechanisms of action, and aims to provide theoretical references for the prevention and treatment of As.