外泌体微小RNA在动脉粥样硬化中的作用研究进展

Research progress on the role of exosomal microRNA in atherosclerosis

摘要:

外泌体(Exo)是由多种细胞分泌被脂质双层膜包裹的微小囊泡,广泛参与细胞间的信息传递,能够携带供体细胞来源的多种活性物质,尤其是微小RNA(miRNA)。近年来,外泌体miRNA在动脉粥样硬化(As)发生发展中的作用及其潜在机制受到了广泛关注和深入研究。本文综述了外泌体miRNA在As中的作用,重点探讨其细胞来源及其对受体细胞功能的调控。同时,文章还讨论了其在As的诊断和治疗中的潜在应用价值与前景。

Abstract:

Exosomes (Exo) are small vesicles secreted by various cells and encapsulated by lipid bilayer membranes, which are widely involved in intercellular information communication, and can carry diverse bioactive molecules derived from donor cells, especially microRNA (miRNA). In recent years, the functions and potential mechanisms of exosomal miRNAs in the occurrence and development of atherosclerosis (As) have received extensive attention and in-depth study. This review summarizes the roles of exosomal miRNAs in As, focusing on their cellular sources and regulatory effects on the function of recipient cells. Meanwhile, this review also discusses their potential application value and prospect in the diagnosis and therapy of As.