苦参碱与血管重塑

Matrine and vascular remodeling

摘要:

苦参碱(MAT)是从传统中药苦参中提取的天然生物碱,兼具中草药的天然属性与化学药物的明确作用优势,在抗炎、内皮细胞(EC)功能保护和血管平滑肌细胞(VSMC)表型转换等方面发挥广泛的调节作用。近年来,因其多靶点调控特性,MAT在血管重塑领域受到广泛关注。研究表明,MAT通过改善血管内皮细胞(VEC)功能障碍、调控VSMC表型转换及抑制单核/巨噬细胞异常活化与趋化等机制,参与动脉粥样硬化(As)、血管新生及肺动脉高压(PH)等多种血管重塑相关疾病的发生与发展。本文系统综述了MAT在血管重塑中的作用机制,基于此,MAT的应用有望成为未来临床治疗的新方向。

Abstract:

Matrine (MAT) is a natural alkaloid extracted from the traditional Chinese herb Sophora flavescens, combining the natural attributes of herbal medicine with the well-defined efficacy advantages of chemical drugs. It exerts broad regulatory effects in areas such as anti-inflammation, endothelial cell (EC) function protection, and phenotypic switching of vascular smooth muscle cells (VSMC). In recent years, MAT has attracted extensive attention in the field of vascular remodeling due to its multi-targeted regulatory properties. Research indicates that MAT participates in the onset and progression of various vascular remodeling-related diseases, including atherosclerosis (As), angiogenesis, and pulmonary hypertension (PH). Its mechanisms involve improving vascular endothelial cell (EC) dysfunction, regulating the phenotypic switching of VSMC, and inhibiting the abnormal activation and chemotaxis of monocytes/macrophages. This article systematically reviews the mechanisms of MAT in vascular remodeling. Based on this evidence, the application of MAT holds promise as a new direction for future clinical therapies.