GATA4促进细胞衰老及相关疾病进展

GATA4 promotes cellular senescence and the progression of related diseases

摘要:

GATA4是GATA转录因子家族的关键成员,在细胞衰老中起关键作用。GATA4通过慢性炎症、氧化应激、细胞周期、细胞凋亡与代谢改变等机制促进细胞衰老。GATA4促进血管内皮细胞衰老,驱动冠状动脉粥样硬化性心脏病(CAD)的发生发展；GATA4促进病理性心肌组织重构与肥厚及心力衰竭的进展；GATA4促进晶状体上皮细胞衰老,加速老年性白内障(ARC)的发生发展。总之,GATA4在细胞衰老及相关心血管疾病中发挥重要作用,可作为衰老相关疾病诊断和治疗的潜在靶标。

Abstract:

GATA4, a key member of the GATA zinc finger family, plays a crucial role in cellular senescence. GATA4 affects chronic inflammation, oxidative stress, cell cycle progression, apoptosis, and metabolic alterations to facilitate the development of cellular senescence. GATA4 promotes vascular endothelial cell senescence and drives the development of coronary atherosclerotic heart disease (CAD); GATA4 facilitates pathological myocardial tissue remodeling, hypertrophy, and the progression of heart failure; GATA4 accelerates lens epithelial cell senescence, hastening the onset and progression of age-related cataract (ARC). Conclusively, GATA4 plays an important role in cellular senescence and related cardiovascular diseases, and can serve as a potential target for the diagnosis and treatment of age-related diseases.