基于动脉粥样硬化病理基础探讨中药复方的防治特点

Exploring the characteristics of traditional Chinese medicine compounds in the prevention and treatment of atherosclerosis based on its pathological foundations

摘要:

动脉粥样硬化(As)是多种心脑血管疾病的病理基础,其发病机制错综复杂,各个病理环节相互作用、彼此影响,共同调控疾病的发生与发展。中药复方通过调控血管内皮功能、脂质代谢、免疫与炎症反应、氧化应激、肠道菌群、细胞外囊泡、巨噬细胞自噬等病理环节在As的防治中显示独特优势。本文依据As的病理基础,对中药复方防治As的作用特点展开系统剖析,以期为As的研究与防治提供更为充足的理论依据。

Abstract:

Atherosclerosis (As) serves as the pathological basis of various cardiovascular and cerebrovascular diseases. The pathogenesis of As involves intricate and interconnected pathological mechanisms, in which multiple molecular pathways interact synergistically via complex crosstalk to collectively drive disease initiation and progression. Traditional Chinese medicine (TCM) compounds exhibit unique advantages in the prevention and treatment of As by modulating multiple pathological processes, including vascular endothelial function, lipid metabolism, immune and inflammatory responses, oxidative stress, gut microbiota, extracellular vesicles, and macrophage autophagy. Based on the pathological mechanisms of As, this article systematically elucidates the characteristics of TCM compounds in prevention and treatment of As, aiming to provide more comprehensive theoretical evidence for As research and intervention.