IL-24在心血管疾病中的研究进展

Research progress of IL-24 in cardiovascular diseases

摘要:

白细胞介素24(IL-24)是IL-10家族中IL-20亚家族的一员,是首个在黑色素瘤中被分离鉴定出的肿瘤生长抑制因子,具有高度保守性。其功能在不同组织及微环境中具有双重性,可发挥促炎或抗炎的双向效应,在炎症性疾病和癌症等多种疾病中发挥重要作用。近年研究发现,IL-24还可调控平滑肌细胞功能、保护内皮细胞以及调节血管新生,参与动脉粥样硬化及血管钙化等心血管疾病的发生发展,有望成为心血管疾病防治的新靶点。

Abstract:

Interleukin-24 (IL-24), a member of the IL-20 subfamily within the IL-10 family, is the first tumor growth suppressor identified and isolated from melanoma, exhibiting a high degree of evolutionary conservation. Its functions are dual in different tissues and microenvironments, exerting bidirectional pro-inflammatory or anti-inflammatory effects, and play crucial roles in various diseases such as inflammatory disorders and cancers. Recent studies have revealed that IL-24 can also regulate the function of smooth muscle cells, protect endothelial cells, modulate angiogenesis, and participate in the pathogenesis and progression of cardiovascular diseases including atherosclerosis and vascular calcification, making it a promising novel target for the prevention and treatment of cardiovascular diseases.