中性粒细胞与淋巴细胞比值在急性冠脉综合征中的研究进展

Research progress on the neutrophil-to-lymphocyte ratio in acute coronary syndrome

摘要:

急性冠脉综合征(ACS)作为心血管急危重症,其发病机制复杂,与多种炎症因子的相互作用密切相关。目前,ACS的风险评估主要依赖于年龄、血脂、心肌标志物和C反应蛋白等传统危险因素,尚缺乏对炎症状态的动态评估。近年来,中性粒细胞与淋巴细胞比值(NLR)作为一种新兴的炎症标志物,在ACS的风险预测和预后评估中展现出重要的价值。动态监测NLR的变化,有助于更早识别患者的炎症反应状态,从而为制定个体化治疗策略提供科学依据。本文综述了近年来NLR在ACS风险预测领域的研究进展,以期为临床实践提供新的思路和参考。

Abstract:

Acute coronary syndrome (ACS), as a critical cardiovascular emergency, involves a complex pathogenesis closely associated with the interplay of multiple inflammatory factors. Currently, risk assessment for ACS primarily relies on traditional factors such as age, lipid profiles, cardiac biomarkers, and C-reactive protein, yet there remains a lack of dynamic evaluation of inflammatory status. In recent years, the neutrophil-to-lymphocyte ratio (NLR) has emerged as a novel inflammatory marker, demonstrating significant value in risk prediction and prognosis assessment in ACS. Dynamic monitoring of NLR changes can facilitate earlier identification of a patient's inflammatory response, thereby providing a scientific basis for developing individualized treatment strategies. This review summarizes recent research advances in the application of NLR for ACS risk prediction, aiming to offer new insights and references for clinical practice.