血脂变异性与泛血管疾病关系的研究进展

Research progress of the relationship between lipid variability and panvascular disease

摘要:

泛血管疾病(PVD)是一类以动脉粥样硬化为共同病理基础的系统性血管疾病。血脂变异性(LV)升高不仅是心血管疾病(CVD)、脑血管疾病及糖尿病血管病变的独立危险因素,还与全因死亡风险升高及不良预后显著相关。因此,在强化降脂治疗的同时,维持血脂水平的平稳达标,对实现PVD的精准防治具有重要意义。本文综述了近年来关于LV与PVD相关性的研究进展。

Abstract:

Panvascular disease (PVD) represents a category of systemic vascular disorders characterized by atherosclerosis as a common pathological foundation. Elevated lipid variability (LV) is not only an independent risk factor for cardiovascular disease (CVD), cerebrovascular disease, and diabetic vascular complications but is also significantly associated with increased all-cause mortality and poor prognosis. Therefore, alongside intensive lipid-lowering therapy, maintaining stable and target lipid levels is of great significance for achieving precise prevention and treatment of PVD. This article reviews the recent research progress on the correlation between LV and PVD.