基于炎症学说总结四妙勇安汤及其组分防治动脉粥样硬化的研究进展

Research progress on prevention and treatment of atherosclerosis with Simiao Yong'an decoction and its components based on inflammatory theory

摘要:

动脉粥样硬化(As)作为一种慢性炎症性病变,是引起冠心病等心血管疾病(CVD)的主要病因,严重威胁人类健康。炎症反应贯穿于As的全过程,从抗炎角度探讨抗As具有重要意义。近些年四妙勇安汤及其组分被发现具有抗炎、降脂、保护血管等多种药理作用。本文从炎症学说切入,系统总结了四妙勇安汤及其组分基于多通路调控炎症抗As的现代机制,旨在为四妙勇安汤防治As进一步提供理论依据。

Abstract:

Atherosclerosis(As), a chronic inflammatory pathological lesion, is the main cause of cardiovascular diseases(CVD) such as coronary heart disease, posing a serious threat to human health. Inflammatory reaction runs through the entire pathological progression of As, and exploring anti-atherosclerosis strategies from the anti-inflammatory perspective is of important significance. In recent years, Simiao Yong'an decoction and its components have been proven to exert multiple pharmacological effects such as anti-inflammation, lipid regulation and vascular endothelial protection. Starting from the inflammatory theory, this paper systematically summarizes the modern mechanism of Simiao Yong'an decoction and its components against As via regulating inflammation through multiple signaling pathways, so as to provide a theoretical reference for its application in the prevention and treatment of As.